The Top 3 NAD+ Boosters On the Market

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As you’re reading this, there are mind-boggling advances being made in longevity and anti-aging.

In fact, just a couple of years ago, scientists were able to reverse the age of mice by up to 40 years simply by increasing levels of a crucial cellular compound called NAD+.

In fact, according to leading scientists from MIT, Rutgers University, Harvard, and Cornell University, increasing NAD+ is perhaps the most promising anti-aging solution known to man.

There are now several products on the market that have been shown in clinical tests to increase NAD+ levels in humans.

Hundreds-of-thousands of people around the world now use NAD+ boosters every single day to slow down aging, boost energy levels, improve cognition, improve sleep, and prevent heart and brain diseases.

In this article, we’re going to look at how NAD+ works and compare the top 3 NAD+ boosters on the market.

What is NAD+?

NAD+ is very easy to understand. It’s sort of like the “fuel” that each of your cells need to operate.

Think of your body as a big collection of billions of cells. From skin cells and stomach cells to heart, liver, and brain cells, your whole body is made of cells.

Each cell needs power. The powerplant inside all your cells--every single one--is the mitochondria.

Your mitochondria produce all the power that lets you do everything.

Thinking, sleeping, seeing, hearing, digesting food, pumping blood, lifting weights, and walking are all possible because of the power produced by your mitochondria.

NAD+ is a crucial cellular “fuel” that allows your mitochondria to create energy.

Without NAD+, your mitochondria cannot make energy.

But as we age, NAD+ levels start to plummet by 50% every 20 years. You still have NAD+ in your body, but it is drastically reduced.

When NAD+ levels drop, your mitochondria don’t produce as much power so your cells get slower, less effective, and less efficient.

When this happens across your entire body, there are massive and sometimes permanent complications.

This is actually recognized as a serious illness called mitochondrial dysfunction.

In fact, mitochondrial dysfunction is at the heart of nearly every lethal age-related disease, including:

  • Heart disease
  • Alzheimer’s
  • Parkinson’s
  • Arthritis
  • And many more

It is also the cause of fatigue, age-related weight gain, poor sleep, and brain fog.

You can hopefully see whey increasing NAD+ and getting it back to the levels you had when you were younger is a very exciting idea.

The Top 3 NAD+ Boosters

As of right now, there are 3 clear leaders in the NAD+ booster marketing:

What’s interesting is that Tru Niagen and Basis both use the same ingredient to boost NAD+, which is called nicotinamide riboside.

We’ll discuss exactly how it works in just a moment.

The last one, NAD3, uses a unique approach to increasing NAD+ that is different from the others. We’ll get into that as well.

The Drama of Tru Niagen and Basis

Since Tru Niagen and Basis use the exact same ingredient, we will cover these together.

This is also fitting because these two companies are currently locked in a multi-hundred-million dollar lawsuit over the ingredient in their products.

Here’s a quick backstory and then we’ll move on to the more important aspect, which is how their shared ingredient, nicotinamide riboside (NR), works.

The parent company for Tru Niagen is a California-based corporation called Chromadex.

Chromadex also owns the patent on NR.

For several years, ChromaDex’s business model was to license NR to other health companies.

Basis, which is manufactured by New York-based Elysium Health, was one of those companies.

However, from 2016 to 2018, Chromadex decided to change its business model and began revoking the licenses on NR so that its subsidiary, Tru Niagen, would be the only one left.

Here’s where it gets juicy.

After they revoked the licenses, Basis was discovered to still contain NR.

Furthermore, Chromadex also alleges that when they tested bottles of Basis, they found statistically significant amounts of an industrial solvent used in fingernail polish, lacquers, and adhesives.

This means Basis was getting their NR from somewhere else but since Chromadex owns the patent, this was very suspicious.

ChromaDex then sued Elysium for several hundred million dollars and the lawsuit is still ongoing.

How NAD and Nicotinamide Riboside Works

You already learned that your body needs NAD+ in order for your cells’ mitochondria to make energy.

Think of NAD+ production like Henry Ford’s famous assembly line for Model A cars.

Your body uses NR to make NAD+. So NR is one of the crucial ingredients in the “assembly line” of NAD+ production.

In medical terms, this is called a “precursor.” NR is the precursor to NAD+.

So if your body has plummeting levels of NAD+ but then it suddenly gets a flood of NR, it will begin manufacturing NAD+.

NR is a modified and patented form of vitamin B3. But NR is different from other forms of vitamin B3, like niacin or niacinamide, in that it does not cause any kind of “niacin flush.”

That’s one of the huge benefits of taking NR is avoiding the unpleasant effects of other types of B3.

The Next Step in NAD+ Boosters: NAD3

While Tru Niagen and Basis rely on one ingredient to boost NAD+ levels in humans, there is another option.

NAD3 is a product that has recently entered the market as a unique competitor to other NR-based NAD+ boosters.

NAD3 uses a novel and patented combination of 3 different ingredients:

  • Teacrine
  • Wasabi (yes, the green stuff you get with sushi)
  • Copper Niacin

On their own, each of these ingredients are all very powerful and interesting in terms of longevity, anti-inflammation, energy, metabolism, and brain performance.

But when they are combined in the specific dosages included with NAD3, the results they deliver are stunning.

NAD3 is so extremely exciting because in its early tests, it appears to outperform NR on several important health and longevity-related cellular mechanisms.

Let’s first take a look at the mechanism behind how NAD3 works to boost NAD+.

How NAD3 Boosts NAD+

To do that, think back to our analogy for NAD+ production inside the cell: it’s like an assembly line.

NR is just one of the parts that help the body create NAD+.

Well, instead of just increasing one of the parts of the assembly line…

NAD3 is able to boost the entire assembly line, which is called the “salvage NAD biosynthetic pathway.”

This is the primary pathway that allows the body to create NAD+.

From start to finish, each of the three ingredients inside NAD3 works on a different part of the salvage pathway to optimize NAD+ production, reduce oxidative stress, support a healthy metabolism, dramatically reduce inflammation, and fight the process of aging.

Comparing Techniques for NAD+ Boosting

We are just starting to understand the benefits of increasing NAD+ as we age.

We know that more NAD+ benefits the human body in incredibly healthy ways: better metabolism, longer life, sharper rain function, and overall improved cellular health.

But this is just the tip of the iceberg.

The difference between simply increasing NAD+ and optimizing the entire NAD+ pathway is profound.


Because the NAD+ salvage pathway involves a host of other longevity- and health-related compounds, nutrients, and proteins.

For example, there is one particular protein that governs the body’s inflammatory response.

It’s called NLRP3.

Increasing NAD+ causes a dramatic reduction in this protein and reduces inflammation across the body.

We know that diseases like atherosclerosis, Alzheimer’s and Parkinson’s, arthritis and other age-related diseases are linked to inflammation.

Now, if you only increase NAD+ like Basis and Tru Niagen do, you get a reduction in NLRP3.

But if you optimize the entire NAD+ pathway, like with NAD3, it produces an even greater anti-inflammatory response and it lasts for several hours longer.

Similar effects are seen across the NAD+ pathway.

There’s another protein called NRF2. This protein governs our body’s ability to use antioxidants to fight diseases like cancer, heart disease, and neurodegenerative diseases.

Increasing NAD+ on its own does boost NRF2.

But when you optimize the entire NAD+ pathway, you get longer and more pronounced activation.

This is where the field of NAD+ boosting is headed.

We are learning more and more about how our bodies use and create NAD+.

It appears that NAD3 has made the next step forward in how we can experience greater benefits of NAD+ activation.

If you’d like to learn more about NAD3, simply click here to go to our page.