The Science Behind the Top 3 Natural Fat Burning Ingredients

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Nothing makes you miss bulking season like cutting season. Yeah, it’s great to finally see the results of all your hard work. But few people enjoy starting cardio and cutting calories to lose fat. This is probably why fat burners are one of the most popular supplements in the world. 

The great news is that there are some very exciting new fat burning compounds on the market that reduce fat using a number of biological mechanisms other than skyrocketing your heart rate, giving you jitters, and leaving you with a crash of energy afterwards.

Let’s look at the science behind the top 3 natural, stimulant-free fat burning ingredients on the market.


Key Points on C3G

  • C3G is an antioxidant found in the skin of USA-grown purple maize.
  • C3G is a nutrient partitioner. It shuttles nutrients into your muscles for fuel instead of fat cells.
  • C3G also activates the Master Switch of your metabolism, known as AMPK.
  • Activating AMPK is also a potent anti-aging mechanism.

Cyanidin-3-Glucoside (C3G) is one of the most exciting fat eliminating nutrients on the market right now. C3G isn’t a “fat burner” per se. It’s actually an antioxidant. C3G is part of a group of anthocyanins, which are sugar-free compounds that give fruits and vegetables their rich, bright colors.

But the really exciting part about C3G is that it has demonstrated powerful nutrient partitioning properties. That means C3G tells your body to put the nutrients you eat into your muscles instead of your fat cells. It partitions the nutrients and uses them for fuel instead of storing them.

How does it work? Cyanidins have been shown to increase adiponectin levels. Adiponectin is a protein hormone that plays a significant role in metabolizing (burning) glucose and fatty acids, which is why adiponectin levels are lower in obese people than in lean people. Cyanidins also increase phosphorylation, which is the process of creating adenosine triphosphate (ATP), which is the energy that your cells make.

But there’s an even bigger benefit to supplementing with C3G. It is a well-known activator of a metabolic regulator called adenosine monophosphate-activated protein kinase (AMPK). AMPK is a cellular enzyme that is commonly called the “Master Switch” of your metabolism. Higher levels of AMPK have been shown to reduce fat storage. AMPK can also stimulate glucose uptake in skeletal muscles. On top of that, declining AMPK levels have been identified as one of the key mechanisms in the process of aging. 

People who take C3G often report that they don’t “feel” anything but they still see remarkable results. This is because C3G works behind the scenes on the cellular mechanisms of fat storage and energy production.

Want to experience C3G for yourself? Try it today

Conjugated Linoleic Acid (CLA)

Key Points

  • CLA is a fatty acid produced in the digestive tracts of certain grass-fed animals. 
  • Researchers are unsure of precisely how CLA works.
  • But in sufficient quantities (3.2g per day) CLA reduced fat mass by .2lbs per week in some studies.

Conjugated linoleic acid (CLA) is an ingredient that you’ll see in many different weight loss supplements. It’s been around for some time now and It is part of a family of fatty acids that are naturally produced in the digestive tracts of certain grass-fed animals like cows, goats, sheep, and buffalo. It also contains Omega 6 fatty acid, which is one of the healthy fats that our bodies need.

Despite several human clinical studies on CLA, we still don’t know exactly how it works. Some researchers believe CLA lowers the melting point of fat. It could also stop fat cells from growing and might increase the speed of fat burning. But more research is needed to determine exactly how CLA works. 

But does it help you lose fat? That’s another interesting thing about CLA. The research on it appears to be inconsistent. There are some human studies that show it does reduce fat significantly. In one 2007 human trial, CLA reduced subjects’ body fat mass by .2 pounds per week. However, subjects took 3.2 grams (3,200mg) of CLA every single day. If you look at many of the popular fat burners on the market they don’t even come close to that dosage level.

If you’ve had success with CLA then by all means continue using it. But for some people who haven’t seen the results they want it could be because of a lack of research into exactly how it interacts with our metabolism and fat tissues. 


Key Points

  • L-Carnitine is created in your liver and it is related to the B Vitamin family. 
  • The job of L-Carnitine is to move long-chain fatty acids into your mitochondria for fuel.
  • It can help you burn fat, reduce fatigue and lactic acid build up, and even increase androgen receptors in your muscles.
  • L-Carnitine L-Tartrate is absorbed faster but Acetyl L-Carnitine can breach the blood-brain barrier for mental focus and protection.

L-Carnitine is a very common fat burner that you may see added to other supplements. You’ll see it listed on supplement labels in a couple different forms: L-Carnitine L-Tartrate or Acetyl L-Carnitine.

Your body actually manufactures L-Carnitine in your liver. It is then transported and stored in tissues throughout your body, especially your heart, muscle, and brain. Because your body can make L-Carnitine it is not an essential nutrient. But supplementing your diet with L-Carnitine has been shown to have some pretty significant benefits.

So what is it and how does it work? Carnitine is a relative of the B Vitamin family, although it’s neither a vitamin nor an amino acid. Its job is to shuttle long-chain fatty acids directly into your mitochondria where they are oxidized and turned into ATP for energy. 

The difference between L-Carnitine L-Tartrate and Acetyl L-Carnitine is subtle but it’s worth discussing. The L-Carnitine L-Tartrate form is a salt of L-Carnitine. It is usually used in athletic supplements because it absorbs and gets into your bloodstream faster. 

Acetyl L-Carnitine is used more for mental enhancement because in this form it is able to cross the blood-brain barrier. Acetyl L-Carnitine has been shown to protect the brain from certain oxidative damage, especially that caused by drinking alcohol.

The great thing about L-Carnitine is that the research is there to back it up. In some studies, test subjects taking 2g of L-Carnitine burned 55% more muscle glycogen and increase fat burning by 55%. The test subjects also built up less lactic acid and retained more creatine phosphate. There are also multiple studies showing that it protects muscle during strenuous activities and prevents fat storage from eating excess carbohydrates. 

Even more interesting is that another study out of the University of Connecticut demonstrated that L-Carnitine increases the number of androgen receptors in muscle tissues, meaning that the hormonal (testosterone) response to exercise was greater. 

If you’re thinking about using a fat burner, there are some very effective found-in-nature ingredients that offer research-backed results. Based on current research, it seems like C3G and L-Carnitine could be your best option for burning fat naturally without using a stimulant. 

M6 by High Performance Nutrition is a C3G supplement derived from non-GMO Purple Maize grown in the USA. M6 is one of our most popular fat burning products because our staff and our customers get incredible results with it every single time. Every batch of M6 is tested for purity by the BSCG and certified Safe for Sport by the NSF.